Ionia
- Airai, Ionia
- Chios, Ionia
- Ephesos Hinterlands
- Ephesos, Ionia
- Erythrai, Ionia
- Klazomenai, Ionia
- Kolophon, Ionia
- Lebedos-Ptolemais, Ionia
- Leukai, Ionia
- Magnesia ad Maeander, Ionia
- Metropolis, Ionia
- Miletos
- Myos, Ionia
- Naulochos, Ionia
- Pedasa, Ionia
- Phokaia, Ionia
- Phygela, Ionia
- Priene, Ionia
- Samos, Ionia
- Smyrna as Eurydikeia
- Smyrna, Ionia
- Teos, Ionia
Abdera begun as a colony of Klazomenai.
Ephesos is burned by Kimmerians.
King Croesus of the Lydians conquers Ephesos.
King Croesus of Lydia is defeated by the Persian general Harpagos. As a result, Ephesos comes under Persian rule.
Histaios of Miletos founds the city of Myrkinos, on the site of what later would be Amphipolis. Aristagoras, also of Miletos, would later occupy the city and perish in the siege of a nearby town.
The Battle of Lade is fought between the Ionians under Dionysos of Phokaia and the Persians. Chios has the largest contingent, followed by Miletos, Lesbos (probably Mytilene), Samos, Teos, Priene, Erythrai, Myos, and Phokaia. Most fled during the battle, but the Chians put up a bold resistance before defeat.
August 27
Chios, Erythrai, and Klazomenai revolt against Athens and is besieged until relieved by Sparta.
May
During a battle between Deryklidas of Sparta and Pharnabazos with Tissaphernes, men from Priene and Achilleion fighting with the Spartans fled. Hamaxitos thus receives its freedom again.
Eresos, Byzantion, Chios,Mytilene, Methymna, Rhodes, Thebes, Korkyra, Eretria, Kios, Samos, Naxos, Andros, Myrina (Lembos), Hephaistia, Imbros, and Thasos join the Second Athenian League, reaffirming its alliance with Athens in response to the growing threat of Persian interference and internal Greek conflicts.
355 BCE
The Temple of Artemis at Ephesos is burned down by a lunatic who did so to become famous for burning it down.
The Persians are driven out of Assos and Ephesos by Alexander the Great.
Erythrai submits to Alexander the Great, who plans to create a canal on the peninsula to connect Teos to Smyrna.
April
Alexander the Great returns to Memphis and is informed that the oracles at Didama and Erythrai proclaimed him a son of Zeus.
Ephesos comes under Lysimachos, who forces everyone to move to a new settlement that he names after his wife Arsinoe.
Lysimachos executes his son Agathokles for treason, and Ephesos revolts as a result.
Lysimachos defeated at the Battle of Coropedion. Adramytteion, Ainos, and Abydos come under control of the Seleukid Empire. Ephesos returns to its original name.
Abydos and Ephesos conquered by Ptolemy III of Egypt.
Antiochos III, desiring to meet Rome in battle, is detained by the cities of Alexandria Troas, Smyrna, and Lampsakos, which refused entreaties.
Antiochos III is defeated by Scipio Asiaticus at the Battle of Magnesia. Through treaty, Ephesos comes under the Attalids.
126 BCE
Manius Aquillius is governor of Asia and rebuilds the road from Adramytteion to Smyrna.
Adramytteion, Ephesos, Pergamon, Magnesia, Tralles, Apamea, Kolophon, Smyrna, and Sardis occupied by Mithridates VI as part of the Mithridatic Wars against Rome.
Ephesos returns to Roman rule and is taxed harshly by Sulla.
King Ptolemy XII Auletes retires to Ephesos when the Roman Senate refuses to reinstate him to the throne.
September 3
Ephesos serves as a naval base for Marc Antony and Kleopatra.
Chios suffers a destructive earthquake but is rebuilt with aid from the Roman Empire.