In 334 BCE, Alexander the Great’s general Parmenion besieged the city after destroying Gyrneion. However, Memnon of Rhodes appeared and Parmenion broke off the siege, per Diodorus Siculus.
In ancient times, the city had two harbors, which was a major advantage. It eventually fell under the control of the Seleukids under Antiochos I Soter. During this time they were able to purchase more territory.
1050 BCE
Pitane is founded by colonists from Lesbos.
600 BCE
335 BCE
Abydos is besieged by Memnon of Rhodes, forcing Parmenion to give up his siege of Pitane.
319 BCE
Herakleitos of Pitane, son of Lysistratos, is honored for some reason in Delphi.
84 BCE
Mithridates VI flees to Pitane to evade Gaius Flavius Fimbria, then moves on to Mytilene.