Tissaphernes is born.
Tissaphernes suppresses the rebellion of Pissuthnes against Darius II.
Under Darius I’s orders, Tissaphernes allies with Sparta over Athens and re-occupies most of the Ionian coast.
Archeptolis, who controls Magnesia ad Maeander, is removed, possibly by Tissaphernes.
Iasos is governed by Amorges, a Persian who had achieved independence from Persia. Iasos is attacked by Spartans, who deliver Amorges to Tissaphernes and plunder the city.
Darius II removes Tissaphernes as a general, though he remains satrap of Caria.
Cyrus the Younger attempts to kill his brother Artaxerxes II at his coronation. Artaxerxes is prevented from killing Cyrus by their mother, so he instead sends him to Asia Minor. Tissaphernes is responsible for divulging the plot.
Tissaphernes tricks the leaders of the 10,000 into joining him for a dinner, then arrests and decapitates them.
During a battle between Deryklidas of Sparta and Pharnabazos with Tissaphernes, men from Priene and Achilleion fighting with the Spartans fled. Hamaxitos and Larissa-Ptolemais thus receive their freedom again.
Tissaphernes is lured out and killed at Kolossai by Tithraustes, supported by Pharnabazos and Parysatis, the mother of Artaxerxes II.