Alexandria ad Issum became the modern day city of İskenderun, Turkey, which I remember as a kid from watching Indiana Jones.
As the name suggests, the city was founded by Alexander the Great and replaces Myriandos as guardian to the Syrian Gates, where he was victorious at the Battle of Issos. A statue was erected in the city to this victory and still stood there in 200 CE.
The city of İskenderun was recently (2023) in the news for heavy damage from a severe earthquake. Coins from the city are rare.
333 BCE
Alexandria ad Issum founded by Alexander III.