Akarnania
- Alyzeia, Akarnania
- Anaktorion, Akarnania
- Argos Amphilochikon, Akarnania
- Echinos
- Koronta, Akarnania
- Leukas, Akarnania
- Medeion, Akarnanai
- Metropolis, Akarnania
- Phytia, Akarnania
- Stratos, Akarnania
- Thyrrheion, Akarnania
A channel that separates the island from the mainland is constructed by Corinthian settlers at Leukas to aid in navigation.
Anaktorion founded by settlers from Corinth.
Corinth obtains control over Anaktorion through fraud after the city had been joinly occupied by Corinth and Korkyra.
The Athenian general Phormio makes his base at Aphytis and leads his army against Pallene. He also takes Argos Amphilochian, removes the Ambrakians, and restores the town to the original inhabitants.
Ambrakians attempt to take Argos Amphilochian but are repulsed.
Sparta under Knemos attempts to take Stratos but are defeated at great loss.
Ambrakia is crushed by Athens in the Battle of Idomene in an attempt to re-take Argos Amphilochian.
Anaktorion is captured by the Acarnanians and Athenians during the Peloponnesian War. The Acarnanians expel the Corinthians from the city, and Anaktorion becomes part of the Acarnanian League.
The Athenian general Demosthenes takes aboard heavy infantry from Zakynthos and Kephallenia (likely including Same) and crosses over to the opposite coast of Akarnania to Alyzeia and Anaktorion, already held by Athens.
Stratos surrenders to King Agesilaos of Sparta.
Iphikrates of Athens invades Thyrrheion.
Medeion maintains its independence from the Aetolian League, unlike many of their neighbors.
Construction of the Temple of Zeus is started at Stratos, but is never finished.
Lysippos creates relief metopes depicting Hercules’ trials for Alyzeia.
Stratos is occupied by Kassander to use as a base against the Aetolian League. He resettles people from elsewhere in Akarnania there.
Stratos is taken by the Aetolian League.
The Aetolian League besieges Medeion, but are defeated by reinforcements sent by Demetrios II of Macedon.
Ambrakia is besieged by Philip V of Macedon, Phytia taken, and Metropolis is burned during the Social War between the Achaean League and the Aetolian League, of which Ambrakia is a member.
Thyrrheion becomes the new capital of Akarnania.
Antiochos III takes Atrax, by then a Roman stronghold, and Medeion.
Ambrakia captured and plundered by the Romans under Marcus Fulvius Nobilior, then declared a free city. Argos Amphilochikan is used as his base.
Cicero arrives at Alyzeia and writes a letter to his friend Tiro.
The population of Stratos is moved to Nicopolis.